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DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways

BACKGROUND: Aberrations in DNA methylation are widespread in colon cancer (CC). Understanding origin and progression of DNA methylation aberrations is essential to develop effective preventive and therapeutic strategies. Here, we aimed to dissect CC subtype-specific methylation instability to unders...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Noreen, Faiza, Küng, Taya, Tornillo, Luigi, Parker, Hannah, Silva, Miguel, Weis, Stefan, Marra, Giancarlo, Rad, Roland, Truninger, Kaspar, Schär, Primo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916434/
https://ncbi.nlm.nih.gov/pubmed/31842975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0791-1
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