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Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming

Critically important to the maintenance of the glutathione (GSH) redox cycle are the activities of many selenocysteine-containing GSH metabolizing enzymes whose translation is controlled by the epitranscriptomic writer alkylation repair homolog 8 (ALKBH8). ALKBH8 is a tRNA methyltransferase that met...

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Pubblicato in:Redox Biol
Autori principali: Lee, May Y., Leonardi, Andrea, Begley, Thomas J., Melendez, J. Andrés
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904832/
https://ncbi.nlm.nih.gov/pubmed/31765888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101375
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