Sirtuin 6 in preosteoclasts suppresses age- and estrogen deficiency-related bone loss by stabilizing estrogen receptor α

Emerging evidence indicates that estrogen receptor (ER) α is an important modulator of bone homeostasis, which occurs partly by promoting osteoclast apoptosis. Sirtuin 6 (Sirt6) is an anti-aging molecule, and its deficiency in mice results in skeletal malformations associated with progeroid features...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Moon, Young Jae, Zhang, Zhongkai, Bang, In Hyuk, Kwon, Oh Kwang, Yoon, Sun-Jung, Kim, Jung Ryul, Lee, Sangkyu, Bae, Eun Ju, Park, Byung-Hyun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889517/
https://ncbi.nlm.nih.gov/pubmed/30787391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0306-9
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