Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT)

[Image: see text] Small molecules that inhibit the metabolic enzyme NAMPT have emerged as potential therapeutics in oncology. As part of our effort in this area, we took a scaffold morphing approach and identified 3-pyridyl azetidine ureas as a potent NAMPT inhibiting motif. We explored the SAR of t...

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Publié dans:ACS Med Chem Lett
Auteurs principaux: Palacios, Daniel S., Meredith, Erik L., Kawanami, Toshio, Adams, Christopher M., Chen, Xin, Darsigny, Veronique, Palermo, Mark, Baird, Daniel, George, Elizabeth L., Guy, Chantale, Hewett, Jeffrey, Tierney, Laryssa, Thigale, Sachin, Wang, Louis, Weihofen, Wilhelm A.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2019
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6862340/
https://ncbi.nlm.nih.gov/pubmed/31749905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00325
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