Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT)

[Image: see text] Small molecules that inhibit the metabolic enzyme NAMPT have emerged as potential therapeutics in oncology. As part of our effort in this area, we took a scaffold morphing approach and identified 3-pyridyl azetidine ureas as a potent NAMPT inhibiting motif. We explored the SAR of t...

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Publicado en:ACS Med Chem Lett
Main Authors: Palacios, Daniel S., Meredith, Erik L., Kawanami, Toshio, Adams, Christopher M., Chen, Xin, Darsigny, Veronique, Palermo, Mark, Baird, Daniel, George, Elizabeth L., Guy, Chantale, Hewett, Jeffrey, Tierney, Laryssa, Thigale, Sachin, Wang, Louis, Weihofen, Wilhelm A.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2019
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6862340/
https://ncbi.nlm.nih.gov/pubmed/31749905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00325
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