Septin 9 isoforms promote tumorigenesis in mammary epithelial cells by increasing migration and ECM degradation through metalloproteinase secretion at focal adhesions.

The cytoskeletal interacting protein Septin 9 (SEPT9), a member of the septin gene family, has been proposed to have oncogenic functions. It is a known hot spot of retroviral tagging insertion and a fusion partner of both de novo and therapy-induced mixed lineage leukemia (MLL). Of all septins, SEPT...

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Bibliografske podrobnosti
izdano v:Oncogene
Main Authors: Marcus, Jenna, Bejerano-Sagie, Michal, Patterson, Nicole, Bagchi, Susmita, Verkhusha, Vladislav V., Connolly, Diana, Goldberg, Gary L., Golden, Aaron, Sharma, Ved P., Condeelis, John, Montagna, Cristina
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6859949/
https://ncbi.nlm.nih.gov/pubmed/31285548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0844-0
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