Spliceosomal disruption of the non-canonical BAF complex in cancer

SF3B1 is the most commonly mutated RNA splicing factor in cancer(1–4), but the mechanisms by which SF3B1 mutations promote malignancy are poorly understood. Here, we integrated pan-cancer splicing analyses with a positive enrichment CRISPR screen to prioritize splicing alterations that promote tumor...

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Udgivet i:Nature
Main Authors: Inoue, Daichi, Chew, Guo-Liang, Liu, Bo, Michel, Brittany C., Pangallo, Joseph, D’Avino, Andrew R., Hitchman, Tyler, North, Khrystyna, Lee, Stanley Chun-Wei, Bitner, Lillian, Block, Ariele, Moore, Amanda R., Yoshimi, Akihide, Escobar-Hoyos, Luisa, Cho, Hana, Penson, Alex, Lu, Sydney X., Taylor, Justin, Chen, Yu, Kadoch, Cigall, Abdel-Wahab, Omar, Bradley, Robert K.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858563/
https://ncbi.nlm.nih.gov/pubmed/31597964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1646-9
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