Insulin enhancement of the antitumor activity of chemotherapeutic agents in colorectal cancer is linked with downregulating PIK3CA and GRB2

The present state of cancer chemotherapy is unsatisfactory. New anticancer drugs that marginally improve the survival of patients continue to be developed at an unsustainably high cost. The study aimed to elucidate the effects of insulin (INS), an inexpensive drug with a convincing safety profile, o...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Agrawal, Siddarth, Woźniak, Marta, Łuc, Mateusz, Makuch, Sebastian, Pielka, Ewa, Agrawal, Anil Kumar, Wietrzyk, Joanna, Banach, Joanna, Gamian, Andrzej, Pizon, Monika, Ziółkowski, Piotr
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851401/
https://ncbi.nlm.nih.gov/pubmed/31719636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53145-x
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