Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes persistent arthritis in a subset of human patients. We report the isolation and functional characterization of monoclonal antibodies (mAbs) from two patients infected with CHIKV in the Dominican Republic. Single B cell sortin...

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Vydáno v:PLoS Pathog
Hlavní autoři: Quiroz, Jose A., Malonis, Ryan J., Thackray, Larissa B., Cohen, Courtney A., Pallesen, Jesper, Jangra, Rohit K., Brown, Rebecca S., Hofmann, Daniel, Holtsberg, Frederick W., Shulenin, Sergey, Nyakatura, Elisabeth K., Durnell, Lorellin A., Rayannavar, Vinayak, Daily, Johanna P., Ward, Andrew B., Aman, M. Javad, Dye, John M., Chandran, Kartik, Diamond, Michael S., Kielian, Margaret, Lai, Jonathan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6837291/
https://ncbi.nlm.nih.gov/pubmed/31697791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008061
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