Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes persistent arthritis in a subset of human patients. We report the isolation and functional characterization of monoclonal antibodies (mAbs) from two patients infected with CHIKV in the Dominican Republic. Single B cell sortin...

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Publicado no:PLoS Pathog
Main Authors: Quiroz, Jose A., Malonis, Ryan J., Thackray, Larissa B., Cohen, Courtney A., Pallesen, Jesper, Jangra, Rohit K., Brown, Rebecca S., Hofmann, Daniel, Holtsberg, Frederick W., Shulenin, Sergey, Nyakatura, Elisabeth K., Durnell, Lorellin A., Rayannavar, Vinayak, Daily, Johanna P., Ward, Andrew B., Aman, M. Javad, Dye, John M., Chandran, Kartik, Diamond, Michael S., Kielian, Margaret, Lai, Jonathan R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6837291/
https://ncbi.nlm.nih.gov/pubmed/31697791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008061
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