Effect of the ratio of betamethasone to TNF-α siRNA co-encapsulated in solid lipid nanoparticles on the acute proinflammatory activity of the nanoparticles

There is evidence that encapsulating glucocorticoids into nucleic acid-containing nanoparticles reduces the inflammatory toxicities of the nanoparticles. Herein, using betamethasone acetate (BA), a glucocorticoid, and a solid lipid nanoparticle formulation of siRNA, we confirmed that co-encapsulatin...

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Publicat a:Mol Pharm
Autors principals: O’Mary, Hannah L., Hanafy, Mahmoud S., Aldayel, Abdulaziz M., Valdes, Solange A., Alzhrani, Riyad F., Hufnagel, Stephanie, Koleng, John J., Cui, Zhengrong
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829045/
https://ncbi.nlm.nih.gov/pubmed/31525980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.9b00629
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