A solid lipid nanoparticle formulation of 4-(N)-docosahexaenoyl 2′, 2′-difluorodeoxycytidine with increased solubility, stability, and antitumor activity

Previously, we synthesized 4-(N)-docosahexaenoyl 2′, 2′-difluorodeoxycytidine (DHA-dFdC), a novel lipophilic compound with a potent, broad-spectrum antitumor activity. Herein, we report a solid lipid nanoparticle (SLN) formulation of DHA-dFdC with improved apparent aqueous solubility, chemical stabi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Int J Pharm
Main Authors: Valdes, Solange A., Alzhrani, Riyad F., Rodriguez, Andres, Lansakara-P, Dharmika S.P., Thakkar, Sachin G., Cui, Zhengrong
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824728/
https://ncbi.nlm.nih.gov/pubmed/31415878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2019.118609
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados