5‐ALA/SFC enhances HO‐1 expression through the MAPK/Nrf2 antioxidant pathway and attenuates murine tubular epithelial cell apoptosis

Cyclosporin A (CsA) is a common immunosuppressant, but its use is limited as it can cause chronic kidney injury. Oxidative stress and apoptosis play a key role in CsA‐induced nephrotoxicity. This study investigated the protective effect of 5‐aminolevulinic acid and iron (5‐ALA/SFC) on CsA‐induced in...

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Vydáno v:FEBS Open Bio
Hlavní autoři: Liu, Chi, Fujino, Masayuki, Zhu, Shuoji, Isaka, Yoshitaka, Ito, Hidenori, Takahashi, Kiwamu, Nakajima, Motowo, Tanaka, Tohru, Zhu, Ping, Li, Xiao‐Kang
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6823284/
https://ncbi.nlm.nih.gov/pubmed/31495071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12729
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