An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo

Mutations and variations in and around SCN5A, encoding the major cardiac sodium channel, influence impulse conduction and are associated with a broad spectrum of arrhythmia disorders. Here, we identify an evolutionary conserved regulatory cluster with super enhancer characteristics downstream of SCN...

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Pubblicato in:Nat Commun
Autori principali: Man, Joyce C. K., Mohan, Rajiv A., Boogaard, Malou van den, Hilvering, Catharina R. E., Jenkins, Catherine, Wakker, Vincent, Bianchi, Valerio, Laat, Wouter de, Barnett, Phil, Boukens, Bastiaan J., Christoffels, Vincent M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821807/
https://ncbi.nlm.nih.gov/pubmed/31666509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12856-5
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