3204 Renin-Angiotensin System Inhibitors Do Not Improve Survival in Fibrillin-1 Hypomorphic Mice with Established Aortic Aneurysm

OBJECTIVES/SPECIFIC AIMS: Drugs to attenuate aortic growth are usually not initiated in patients with Marfan syndrome until aortic dilation is already present. Therefore, we measured the impact of drugs (the renin-angiotensin system inhibitors losartan and enalapril) on survival and thoracic aortic...

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Foilsithe in:J Clin Transl Sci
Main Authors: Sheppard, Mary Burchett, Chen, Jeff Zheying, Rateri, Debra L., Moorleghen, Jessica J., Weiland, Mackenzie, Daugherty, Alan
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cambridge University Press 2019
Ábhair:
Mechanistic Basic to Clinical
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6799274/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/cts.2019.258
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