Increased Sensitivity to Mitochondrial Toxin-Induced Apoptosis in Neural Cells Expressing Mutant Presenilin-1 Is Linked to Perturbed Calcium Homeostasis and Enhanced Oxyradical Production

Many cases of autosomal dominant early onset Alzheimer’s disease (AD) result from mutations in the gene encoding presenilin-1 (PS-1). PS-1 is an integral membrane protein expressed ubiquitously in neurons throughout the brain in which it is located primarily in endoplasmic reticulum (ER). Although t...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:J Neurosci
Autors principals: Keller, Jeffrey N., Guo, Qing, Holtsberg, F. W., Bruce-Keller, A. J., Mattson, Mark P.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 1998
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792705/
https://ncbi.nlm.nih.gov/pubmed/9614221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.18-12-04439.1998
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars