Increased Sensitivity to Mitochondrial Toxin-Induced Apoptosis in Neural Cells Expressing Mutant Presenilin-1 Is Linked to Perturbed Calcium Homeostasis and Enhanced Oxyradical Production

Many cases of autosomal dominant early onset Alzheimer’s disease (AD) result from mutations in the gene encoding presenilin-1 (PS-1). PS-1 is an integral membrane protein expressed ubiquitously in neurons throughout the brain in which it is located primarily in endoplasmic reticulum (ER). Although t...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Keller, Jeffrey N., Guo, Qing, Holtsberg, F. W., Bruce-Keller, A. J., Mattson, Mark P.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1998
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792705/
https://ncbi.nlm.nih.gov/pubmed/9614221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.18-12-04439.1998
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