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Presenilin-1 Mutation Increases Neuronal Vulnerability to Focal Ischemia In Vivo and to Hypoxia and Glucose Deprivation in Cell Culture: Involvement of Perturbed Calcium Homeostasis

Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene. Studies of cultured neural cells suggest that PS1 mutations result in perturbed cellular calcium homeostasis and may thereby render neurons vulnerable to apoptosis. In light of e...

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Detaylı Bibliyografya
Yayımlandı:J Neurosci
Asıl Yazarlar: Mattson, Mark P., Zhu, Haiyan, Yu, Jin, Kindy, Mark S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Society for Neuroscience 2000
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772370/
https://ncbi.nlm.nih.gov/pubmed/10662826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-04-01358.2000
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