Short-term consequences of F508del-CFTR thermal instability on CFTR-dependent transepithelial currents in human airway epithelial cells

Loss-of-function mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) channel in human airway epithelial cells are responsible for Cystic Fibrosis. A deleterious impact of physiological temperature on CFTR plasma membrane expression, residence and channel activity is character...

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Publicado en:Sci Rep
Autores principales: Froux, Lionel, Coraux, Christelle, Sage, Edouard, Becq, Frédéric
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760155/
https://ncbi.nlm.nih.gov/pubmed/31551433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50066-7
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