Activity-based ratiometric FRET probe reveals oncogene-driven changes in labile copper pools induced by altered glutathione metabolism

Copper is essential for life, and beyond its well-established ability to serve as a tightly bound, redox-active active site cofactor for enzyme function, emerging data suggest that cellular copper also exists in labile pools, defined as loosely bound to low-molecular-weight ligands, which can regula...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Chung, Clive Yik-Sham, Posimo, Jessica M., Lee, Sumin, Tsang, Tiffany, Davis, Julianne M., Brady, Donita C., Chang, Christopher J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744846/
https://ncbi.nlm.nih.gov/pubmed/31451653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904610116
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