β-Lactamases and β-Lactamase Inhibitors in the 21st Century

The β-lactams retain a central place in the antibacterial armamentarium. In Gram-negative bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β-lactam ring are the primary resistance mechanism, with multiple enzymes disseminating on mobile genetic elements across opportu...

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Detalles Bibliográficos
Publicado en:J Mol Biol
Main Authors: Tooke, Catherine L., Hinchliffe, Philip, Bragginton, Eilis C., Colenso, Charlotte K., Hirvonen, Viivi H.A., Takebayashi, Yuiko, Spencer, James
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2019
Assuntos:
Review
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6723624/
https://ncbi.nlm.nih.gov/pubmed/30959050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.04.002
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