Two activating mutations of MPL in triple‐negative myeloproliferative neoplasms

MPLW515K or W515L mutation plays an important role in the pathogenesis of myeloproliferative neoplasms (MPNs) through signaling molecules of the cytokine receptor axis. Besides MPLW515K or W515L, more than 30 atypical MPL mutations have been reported in patients who are negative for JAK2V617F, MPLW5...

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Bibliographic Details
Published in:Cancer Med
Main Authors: Xie, Juan, Chen, Xiuhua, Gao, Feng, Hou, Ruixia, Tian, Tingting, Zhang, Yaofang, Fan, Lifang, Hu, Jinjun, Zhu, Guiyang, Yang, Wanfang, Wang, Hongwei
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
Subjects:
Cancer Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718619/
https://ncbi.nlm.nih.gov/pubmed/31294534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.2387
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