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DDX3 Modulates Neurite Development via Translationally Activating an RNA Regulon Involved in Rac1 Activation
The RNA helicase DDX3 is a component of neuronal granules, and its gene mutations are linked to intellectual disability (ID). Here we demonstrate that DDX3 depletion in neurons impairs neurite development by downregulating Rac1 level and activation. Moreover, DDX3 activates the translation of functi...
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| Udgivet i: | J Neurosci |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Society for Neuroscience
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6705563/ https://ncbi.nlm.nih.gov/pubmed/27656019 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4603-15.2016 |
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