Deficiency of p62/Sequestosome 1 Causes Hyperphagia Due to Leptin Resistance in the Brain

The cytoplasmic regulatory protein p62 (Sequestosome 1/A170) is known to modulate various receptor-mediated intracellular signaling pathways. p62 deficiency was shown to result in mature-onset obesity in mice, but the mechanisms underlying this abnormality remained unclear. Here we report that hyper...

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Vydáno v:J Neurosci
Hlavní autoři: Harada, Harumi, Warabi, Eiji, Matsuki, Taizo, Yanagawa, Toru, Okada, Kosuke, Uwayama, Junya, Ikeda, Akira, Nakaso, Kazuhiro, Kirii, Kyoko, Noguchi, Noriko, Bukawa, Hiroki, Siow, Richard C. M., Mann, Giovanni E., Shoda, Junichi, Ishii, Tetsuro, Sakurai, Takeshi
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705174/
https://ncbi.nlm.nih.gov/pubmed/24027277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2954-12.2013
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