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Intracellular nanoparticle delivery by oncogenic KRAS-mediated macropinocytosis
BACKGROUND: The RAS family of oncogenes (KRAS, HRAS, NRAS) are the most frequent mutations in cancers and regulate key signaling pathways that drive tumor progression. As a result, drug delivery targeting RAS-driven tumors has been a long-standing challenge in cancer therapy. Mutant RAS activates ca...
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| Publicat a: | Int J Nanomedicine |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Dove
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6701665/ https://ncbi.nlm.nih.gov/pubmed/31496700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S212861 |
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