Bone marrow–derived mesenchymal stromal cells promote resistance to tyrosine kinase inhibitors in chronic myeloid leukemia via the IL-7/JAK1/STAT5 pathway

Chronic myeloid leukemia (CML) is caused by the fusion of the BCR activator of RhoGEF and GTPase activating protein (BCR) and ABL proto-oncogene, the nonreceptor tyrosine kinase (ABL) genes. Although the tyrosine kinase inhibitors (TKIs) imatinib (IM) and nilotinib (NI) have remarkable efficacy in m...

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Vydáno v:J Biol Chem
Hlavní autoři: Zhang, Xiaoyan, Tu, Huaijun, Yang, Yazhi, Jiang, Xiaoyan, Hu, Xianliang, Luo, Qidong, Li, Jian
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690703/
https://ncbi.nlm.nih.gov/pubmed/31235520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008037
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