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Metabolic Stress Induces Caspase-3 Mediated Degradation and Inactivation of Farnesyl and Geranylgeranyl Transferase Activities in Pancreatic β-Cells

BACKGROUND/AIMS: At least 300 prenylated proteins are identified in the human genome; the majority of which partake in a variety of cellular processes including growth, differentiation, cytoskeletal organization/dynamics and vesicle trafficking. Aberrant prenylation of proteins is implicated in huma...

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Bibliografski detalji
Izdano u:Cell Physiol Biochem
Glavni autori: Veluthakal, Rajakrishnan, Arora, Daleep K., Goalstone, Marc L., Kowluru, Renu A., Kowluru, Anjaneyulu
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6685439/
https://ncbi.nlm.nih.gov/pubmed/27802439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000447907
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