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The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer’s amyloid pathology
The membrane-anchored CX3CL1 is best known to exert its signaling function through binding its receptor CX3CR1. This study demonstrates a novel function that CX3CL1 exerts. CX3CL1 is sequentially cleaved by α-, β-, and γ-secretase, and the released CX3CL1 intracellular domain (CX3CL1-ICD) would tran...
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| Publicado no: | J Exp Med |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6683996/ https://ncbi.nlm.nih.gov/pubmed/31209068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20182238 |
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