Histopathological and Molecular Signatures of a Mouse Model of Acute-on-Chronic Alcoholic Liver Injury Demonstrate Concordance With Human Alcoholic Hepatitis

Human alcoholic hepatitis (AH) carries a high mortality rate. AH is an acute-on-chronic form of liver injury characterized by hepatic steatosis, ballooned hepatocytes, neutrophil infiltration, and pericellular fibrosis. We aimed to study the pathogenesis of AH in an animal model which combines chron...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Furuya, Shinji, Cichocki, Joseph A, Konganti, Kranti, Dreval, Kostiantyn, Uehara, Takeki, Katou, Yuuki, Fukushima, Hisataka, Kono, Hiroshi, Pogribny, Igor P, Argemi, Josepmaria, Bataller, Ramon, Rusyn, Ivan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Molecular, Biochemical, and Systems Toxicology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657579/
https://ncbi.nlm.nih.gov/pubmed/30517762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy292
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