NMR Fragment-Based Screening against Tandem RNA Recognition Motifs of TDP-43

The TDP-43 is originally a nuclear protein but translocates to the cytoplasm in the pathological condition. TDP-43, as an RNA-binding protein, consists of two RNA Recognition Motifs (RRM1 and RRM2). RRMs are known to involve both protein-nucleotide and protein-protein interactions and mediate the fo...

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Bibliografske podrobnosti
izdano v:Int J Mol Sci
Main Authors: Nshogoza, Gilbert, Liu, Yaqian, Gao, Jia, Liu, Mingqing, Moududee, Sayed Ala, Ma, Rongsheng, Li, Fudong, Zhang, Jiahai, Wu, Jihui, Shi, Yunyu, Ruan, Ke
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6651732/
https://ncbi.nlm.nih.gov/pubmed/31262091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20133230
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