Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease?

Zinc transporter-3 (ZnT3) protein controls synaptic vesicular Zn(2+) levels, which is predicted to regulate normal cognitive function. Surprisingly, previous studies found that 6- to 10-week-old ZnT3 knock-out (KO) mice did not show impairment in the Morris water maze. We hypothesized that older ZnT...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Adlard, Paul A., Parncutt, Jacqui M., Finkelstein, David I., Bush, Ashley I.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2010
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Brief Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633978/
https://ncbi.nlm.nih.gov/pubmed/20130173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5255-09.2010
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