Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene Expression

Inhibitors of DNA topoisomerase I (TOP1), an enzyme relieving torsional stress of DNA by generating transient single-strand breaks, are clinically used to treat ovarian, small cell lung and cervical cancer. As torsional stress is generated during transcription by progression of RNA polymerase II thr...

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Publicado en:Cancers (Basel)
Autores principales: Riedlinger, Tabea, Bartkuhn, Marek, Zimmermann, Tobias, Hake, Sandra B., Nist, Andrea, Stiewe, Thorsten, Kracht, Michael, Schmitz, M. Lienhard
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6627772/
https://ncbi.nlm.nih.gov/pubmed/31242600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11060883
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