Increased 20-HETE Synthesis Explains Reduced Cerebral Blood Flow But Not Impaired Neurovascular Coupling after Cortical Spreading Depression in Rat Cerebral Cortex

Cortical spreading depression (CSD) is associated with release of arachidonic acid, impaired neurovascular coupling, and reduced cerebral blood flow (CBF), caused by cortical vasoconstriction. We tested the hypothesis that the released arachidonic acid is metabolized by the cytochrome P450 enzyme to...

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Publicado no:J Neurosci
Main Authors: Fordsmann, Jonas C., Ko, Rebecca W. Y., Choi, Hyun B., Thomsen, Kirsten, Witgen, Brent M., Mathiesen, Claus, Lønstrup, Micael, Piilgaard, Henning, MacVicar, Brian A., Lauritzen, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6619145/
https://ncbi.nlm.nih.gov/pubmed/23392684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2308-12.2013
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