CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

Using biochemical characterization of fusion proteins associated with endometrial stromal sarcoma, we identified JAZF1 as a new subunit of the NuA4 acetyltransferase complex and CXORF67 as a subunit of the Polycomb Repressive Complex 2 (PRC2). Since CXORF67’s interaction with PRC2 leads to decreased...

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Vydáno v:Sci Adv
Hlavní autoři: Piunti, Andrea, Smith, Edwin R., Morgan, Marc A. J., Ugarenko, Michal, Khaltyan, Natalia, Helmin, Kathryn A., Ryan, Caila A., Murray, David C., Rickels, Ryan A., Yilmaz, Bahar D., Rendleman, Emily J., Savas, Jeffrey N., Singer, Benjamin D., Bulun, Serdar E., Shilatifard, Ali
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609211/
https://ncbi.nlm.nih.gov/pubmed/31281901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax2887
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