CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

Using biochemical characterization of fusion proteins associated with endometrial stromal sarcoma, we identified JAZF1 as a new subunit of the NuA4 acetyltransferase complex and CXORF67 as a subunit of the Polycomb Repressive Complex 2 (PRC2). Since CXORF67’s interaction with PRC2 leads to decreased...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Piunti, Andrea, Smith, Edwin R., Morgan, Marc A. J., Ugarenko, Michal, Khaltyan, Natalia, Helmin, Kathryn A., Ryan, Caila A., Murray, David C., Rickels, Ryan A., Yilmaz, Bahar D., Rendleman, Emily J., Savas, Jeffrey N., Singer, Benjamin D., Bulun, Serdar E., Shilatifard, Ali
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609211/
https://ncbi.nlm.nih.gov/pubmed/31281901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax2887
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