α(2)δ3 Is Essential for Normal Structure and Function of Auditory Nerve Synapses and Is a Novel Candidate for Auditory Processing Disorders

The auxiliary subunit α(2)δ3 modulates the expression and function of voltage-gated calcium channels. Here we show that α(2)δ3 mRNA is expressed in spiral ganglion neurons and auditory brainstem nuclei and that the protein is required for normal acoustic responses. Genetic deletion of α(2)δ3 led to...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Pirone, Antonella, Kurt, Simone, Zuccotti, Annalisa, Rüttiger, Lukas, Pilz, Peter, Brown, David H., Franz, Christoph, Schweizer, Michaela, Rust, Marco B., Rübsamen, Rudolf, Friauf, Eckhard, Knipper, Marlies, Engel, Jutta
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608152/
https://ncbi.nlm.nih.gov/pubmed/24403143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3085-13.2014
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