Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly

The mechanistic target of rapamycin (mTOR) kinase forms two multi-protein signaling complexes, mTORC1 and mTORC2, which are master regulators of cell growth, metabolism, survival and autophagy. Two of the subunits of these complexes are mLST8 and Raptor, β-propeller proteins that stabilize the mTOR...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Cuéllar, Jorge, Ludlam, W. Grant, Tensmeyer, Nicole C., Aoba, Takuma, Dhavale, Madhura, Santiago, César, Bueno-Carrasco, M. Teresa, Mann, Michael J., Plimpton, Rebecca L., Makaju, Aman, Franklin, Sarah, Willardson, Barry M., Valpuesta, José M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599039/
https://ncbi.nlm.nih.gov/pubmed/31253771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10781-1
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