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Imaging Insulin Secretion from Mouse Pancreas by MRI Is Improved by Use of a Zinc-Responsive MRI Sensor with Lower Affinity for Zn(2+) Ions
It has been demonstrated that divalent zinc ions packaged with insulin in β-cell granules can be detected by MRI during glucose-stimulated insulin secretion using a gadolinium-based Zn(2+)-sensitive agent. This study was designed to evaluate whether a simpler agent design having single Zn(2+)-sensin...
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| Veröffentlicht in: | J Am Chem Soc |
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| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6594366/ https://ncbi.nlm.nih.gov/pubmed/30484648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b07607 |
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