Purification of glycosylphosphatidylinositol-anchored mucins from Trypanosoma cruzi trypomastigotes and synthesis of α-Gal-containing neoglycoproteins: application as biomarkers for reliable diagnosis and early assessment of chemotherapeutic outcomes of Chagas disease

Chagas disease (ChD), caused by the protozoan parasite Trypanosoma cruzi, affects millions of people worldwide. Chemotherapy is restricted to two drugs, which are partially effective and may cause severe side effects, leading to cessation of treatment in a significant number of patients. Currently,...

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Pubblicato in:Methods Mol Biol
Autori principali: Ortega-Rodriguez, Uriel, Portillo, Susana, Ashmus, Roger A., Duran, Jerry A., Schocker, Nathaniel S., Iniguez, Eva, Montoya, Alba L., Zepeda, Brenda G., Olivas, Janet J., Karimi, Nasim H., Alonso-Padilla, Julio, Izquierdo, Luis, Pinazo, Maria-Jesús, de Noya, Belkisyolé Alarcón, Noya, Oscar, Maldonado, Rosa A., Torrico, Faustino, Gascón, Joaquim, Michael, Katja, Almeida, Igor C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589430/
https://ncbi.nlm.nih.gov/pubmed/30868536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-9148-8_22
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