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Protein kinase C binding protein 1 inhibits hypoxia-inducible factor-1 in the heart

AIMS: Hypoxia-inducible factor-1 alpha (HIF-1α) is a key transcription factor responsible for the induction of genes that facilitate adaptation to hypoxia. To study HIF-1 signalling in the heart, we developed a mouse model in which an oxygen-stable form of HIF-1α can be inducibly expressed in cardia...

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Publicat a:Cardiovasc Res
Autors principals: Schunke, Kathryn J, Walton, Chad B, Veal, David R, Mafnas, Chrisy T, Anderson, Cynthia D, Williams, Allison L, Shohet, Ralph V
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587917/
https://ncbi.nlm.nih.gov/pubmed/30395227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvy278
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