Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications

BACKGROUND: Overcoming oxidative stress is a critical step for tumor progression; however, the underlying mechanisms in colorectal cancer (CRC) remain unclear. METHODS: We investigated nicotinamide adenine dinucleotide (phosphate) (NAD(P))-dependent enzyme methylene tetrahydrofolate dehydrogenase 2...

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Udgivet i:J Natl Cancer Inst
Main Authors: Ju, Huai-Qiang, Lu, Yun-Xin, Chen, Dong-Liang, Zuo, Zhi-Xiang, Liu, Ze-Xian, Wu, Qi-Nian, Mo, Hai-Yu, Wang, Zi-Xian, Wang, De-Shen, Pu, Heng-Ying, Zeng, Zhao-Lei, Li, Bo, Xie, Dan, Huang, Peng, Hung, Mien-Chie, Chiao, Paul J, Xu, Rui-Hua
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579745/
https://ncbi.nlm.nih.gov/pubmed/30534944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djy160
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