Alzheimer’s Presenilin Mutation Sensitizes Neural Cells to Apoptosis Induced by Trophic Factor Withdrawal and Amyloid β-Peptide: Involvement of Calcium and Oxyradicals

Most autosomal dominant inherited forms of early onset Alzheimer’s disease (AD) are caused by mutations in the presenilin-1 (PS-1) gene on chromosome 14. PS-1 is an integral membrane protein with six to nine membrane-spanning domains and is expressed in neurons throughout the brain wherein it is loc...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Guo, Qing, Sopher, Bryce L., Furukawa, Katsutoshi, Pham, Dao G., Robinson, Nic, Martin, George M., Mattson, Mark P.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1997
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6573527/
https://ncbi.nlm.nih.gov/pubmed/9151738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-11-04212.1997
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