Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing

The bioactive lipid mediator sphingosine 1-phosphate (S1P) was recently assigned critical roles in platelet biology: whereas S1P(1) receptor-mediated S1P gradient sensing was reported to be essential for directing proplatelet extensions from megakaryocytes (MKs) toward bone marrow sinusoids, MK sphi...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Niazi, Hira, Zoghdani, Nesrine, Couty, Ludovic, Leuci, Alexandre, Nitzsche, Anja, Allende, Maria L., Mariko, Boubacar, Ishaq, Rameez, Aslan, Yetki, Becker, Pierre Hadrien, Gazit, Salomé L., Poirault-Chassac, Sonia, Decouture, Benoit, Baudrie, Veronique, De Candia, Erica, Kono, Mari, Benarab, Ammar, Gaussem, Pascale, Tharaux, Pierre-Louis, Chun, Jerold, Provot, Sylvain, Debili, Najet, Therond, Patrice, Proia, Richard L., Bachelot-Loza, Christilla, Camerer, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6560353/
https://ncbi.nlm.nih.gov/pubmed/31171507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019031948
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