Computational modeling of retinal hypoxia and photoreceptor degeneration in patients with age-related macular degeneration

Although drusen have long been acknowledged as a primary hallmark of dry age-related macular degeneration (AMD) their role in the disease remains unclear. We hypothesize that drusen accumulation increases the barrier to metabolite transport ultimately resulting in photoreceptor cell death. To invest...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: McHugh, Kevin J., Li, Dian, Wang, Jay C., Kwark, Leon, Loo, Jessica, Macha, Venkata, Farsiu, Sina, Kim, Leo A., Saint-Geniez, Magali
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559637/
https://ncbi.nlm.nih.gov/pubmed/31185022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0216215
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