A Randomized Phase II Study of Cabozantinib Versus Weekly Paclitaxel in the Treatment of Persistent or Recurrent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer: an NRG Oncology/Gynecologic Oncology Group Study

INTRODUCTION: Cabozantinib is a receptor tyrosine kinases inhibitor that targets MET (c-MET), VEGF receptor 2 (VEGFR2), RET, AXL, KIT, FLT-3, and TIE-2 and previously showed promising single agent activity in recurrent ovarian cancer. METHODS: This was an open label, 1:1 randomized study of cabozant...

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Vydáno v:Gynecol Oncol
Hlavní autoři: Matulonis, Ursula A., Sill, Michael W., Makker, Vicky, Mutch, David G., Carlson, Jay W., Darus, Christopher J., Mannel, Robert S., Bender, David P., Crane, Erin K., Aghajanian, Carol
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542283/
https://ncbi.nlm.nih.gov/pubmed/30587441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2018.12.008
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