Exosomes derived from M1 macrophages aggravate neointimal hyperplasia following carotid artery injuries in mice through miR-222/CDKN1B/CDKN1C pathway

The role of M1 macrophages (M1M)-derived exosomes in the progression of neointimal hyperplasia remains unclear now. Using a transwell co-culture system, we demonstrated that M1M contributed to functional change of vascular smooth muscle cell (VSMC). We further stimulated VSMCs with exosomes isolated...

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Pubblicato in:Cell Death Dis
Autori principali: Wang, Zeng, Zhu, Hong, Shi, Hongtao, Zhao, Huan, Gao, Rifeng, Weng, Xinyu, Liu, Rongle, Li, Xiao, Zou, Yunzeng, Hu, Kai, Sun, Aijun, Ge, Junbo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6541659/
https://ncbi.nlm.nih.gov/pubmed/31142732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1667-1
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