Derivatives of Ribosome-Inhibiting Antibiotic Chloramphenicol Inhibit the Biosynthesis of Bacterial Cell Wall

Here, we describe the preparation and evaluation of α,β-unsaturated carbonyl derivatives of the bacterial translation inhibiting antibiotic chloramphenicol (CAM). Compared to the parent antibiotic, two compounds containing α,β-unsaturated ketones (1 and 4) displayed a broader spectrum of activity ag...

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Vydáno v:ACS Infect Dis
Hlavní autoři: Zada, Sivan Louzoun, Green, Keith D., Shrestha, Sanjib K., Herzog, Ido M., Garneau-Tsodikova, Sylvie, Fridman, Micha
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6536003/
https://ncbi.nlm.nih.gov/pubmed/29714997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.8b00078
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