Low Antituberculosis Drug Concentrations in HIV-Tuberculosis-Coinfected Adults with Low Body Weight: Is It Time To Update Dosing Guidelines?

Antituberculosis drugs display large pharmacokinetic variability, which may be influenced by several factors, including body size, genetic differences, and drug-drug interactions. We set out to determine these factors, quantify their effect, and determine the dose adjustments necessary for optimal d...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Sekaggya-Wiltshire, Christine, Chirehwa, Maxwell, Musaazi, Joseph, von Braun, Amrei, Buzibye, Allan, Muller, Daniel, Gutteck, Ursula, Motta, Ilaria, Calcagno, Andrea, Fehr, Jan S., Kambugu, Andrew, Castelnuovo, Barbara, Lamorde, Mohammed, Denti, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535538/
https://ncbi.nlm.nih.gov/pubmed/30910890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02174-18
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