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Impact of selective immune-cell depletion on growth of Mycobacterium tuberculosis (Mtb) in a whole-blood bactericidal activity (WBA) assay

We investigated the contribution of host immune cells to bacterial killing in a whole-blood bactericidal activity (WBA) assay, an ex vivo model used to test efficacy of drugs against mycobacterium tuberculosis (Mtb). We performed WBA assays with immuno-magnetic depletion of specific cell types, in t...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cross, Gail B., Yeo, Benjamin C-M, Hutchinson, Paul Edward, Tan, Mark C., Verma, Rupangi, Lu, Qingshu, Paton, Nicholas I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6524797/
https://ncbi.nlm.nih.gov/pubmed/31100071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0216616
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