Variation in assembly stoichiometry in non‐metazoan homologs of the hub domain of Ca(2+)/calmodulin‐dependent protein kinase II

The multi‐subunit Ca(2+)/calmodulin‐dependent protein kinase II (CaMKII) holoenzyme plays a critical role in animal learning and memory. The kinase domain of CaMKII is connected by a flexible linker to a C‐terminal hub domain that assembles into a 12‐ or 14‐subunit scaffold that displays the kinase...

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Vydáno v:Protein Sci
Hlavní autoři: McSpadden, Ethan D., Xia, Zijie, Chi, Chris C., Susa, Anna C., Shah, Neel H., Gee, Christine L., Williams, Evan R., Kuriyan, John
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511747/
https://ncbi.nlm.nih.gov/pubmed/30942928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3614
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